The role of sulfobutyl ether beta cyclodextrin in preparation

Sulfobutyl betac yclodextrin (SBE- beta -CD) as medicinal materials with excellent properties, has good water solubility, inclusion ability, low renal toxicity, hemolysis, characteristics of local mild irritation and oral or injection safety, has received wide attention in the field of medicine. Its function in different preparations is as follows:

In an oral preparation

The solubility difference is one of the main reasons of low oral bioavailability of insoluble drugs, beta SBE- -CD can be used as inclusion material and insoluble drug clathrate formation, so as to improve the solubility of insoluble drugs, can increase the oral bioavailability. In addition, it can increase the stability of the drug, reduce the irritation of the drug, and conceal the bad smell or taste of the medicine.

In the injection

SBE- beta -CD not only can increase drug solubility, improve the stability and safety of the drug, it can reduce the stimulation to the injection site of administration, the drug quickly reaches the blood concentration required, prolong the time of drug action.

In the nasal administration preparation

Intranasal drug having rapid absorption, fast acting, high bioavailability, convenient administration, easy to be accepted by patients, and can avoid the liver first pass effect and other advantages, has become one of the hotspots in pharmaceutical research. However, due to low penetration of nasal drugs, many enzymes in the nasal cavity can cause degradation and nasal adhesion

Membrane cilia have strong scavenging function and other physiological factors, which affect the absorption of drugs. SBE- beta -CD can improve the solubility and stability of drugs, increase the permeability of nasal mucosa, and improve the bioavailability of nasal medicine.